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Key Points Question Is obstructive sleep apnea (OSA) associated with cognition and white matter (WM) integrity over time? Findings In this cohort study of 1110 participants, OSA was associated with… Click to show full abstract
Key Points Question Is obstructive sleep apnea (OSA) associated with cognition and white matter (WM) integrity over time? Findings In this cohort study of 1110 participants, OSA was associated with impaired cognition and WM integrity during 4 years of follow-up. Incident and persistent OSA were associated with accelerated attention, visual processing, and visual memory decline, which correlated with changes in fractional anisotropy of the relevant WM areas. Age and sex were associated with modifying the associations. Meaning These findings suggest that timely evaluation and adequate intervention of OSA could aid in preserving brain health, improving cognition, and reducing the risk of cognitive impairment.
Journal Title: JAMA Network Open
Year Published: 2022
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