LAUSR

Key Points Question Are cerebrospinal fluid (CSF) neurofilament heavy (cNfH) levels associated with clinical progression in patients with Parkinson disease? Findings In this cohort study of 404 patients with Parkinson disease, higher baseline cNfH levels were associated with faster worsening of motor and cognitive symptoms. In addition, cNfH levels were associated with levels of other CSF biomarkers (ie, α-synuclein, amyloid-β 1-42, phosphorylated tau at threonine 181 position, and total tau) at baseline. Meaning These findings suggest that cNfH levels may be useful in stratifying patients with Parkinson disease who have different progression rates; however, this finding should be investigated further.