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Key Points Question What is the relative prevalence of congenital heart defects among boys born with hypospadias compared with boys born without hypospadias? Findings In this large multistate birth defects… Click to show full abstract
Key Points Question What is the relative prevalence of congenital heart defects among boys born with hypospadias compared with boys born without hypospadias? Findings In this large multistate birth defects registry cohort study of data from population-based birth defect surveillance programs on all male infants born in 11 US states, boys born with hypospadias were 6 times more likely than boys without hypospadias to have any major congenital heart defect. Meaning This study suggests that screenings for additional birth defects among boys born with hypospadias may be warranted; in addition, molecular studies are needed to uncover the shared etiology of co-occurring defects in different developmental fields.
Journal Title: JAMA Network Open
Year Published: 2022
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