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Key Points Question What is the durability associated with 2 doses of the BNT162b2 COVID-19 vaccine against Delta- and Omicron-related emergency department and urgent care encounters among adolescents aged 12… Click to show full abstract
Key Points Question What is the durability associated with 2 doses of the BNT162b2 COVID-19 vaccine against Delta- and Omicron-related emergency department and urgent care encounters among adolescents aged 12 to 17 years, and is a third dose associated with improved protection? Findings In this case-control study including 3168 adolescents, estimated effectiveness of 2 doses of BNT162b2 was highest against both Delta (89%) and Omicron (73%) less than 2 months after vaccination but waned to 49% against Delta and 16% against Omicron at 6 months and beyond. Estimated effectiveness of 3 doses of BNT162b2 against Omicron was 87%. Meaning These findings suggest that third doses are needed to achieve peak protection for adolescents and may help mitigate against a future surge in cases.
Journal Title: JAMA Network Open
Year Published: 2022
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