LAUSR

Key Points Question Are human papillomavirus (HPV) vaccinations and screening associated with trends in HPV-associated cancers in the US? Findings In this cross-sectional study using 3 national databases, the incidence of cervical cancer has decreased, especially in younger women, after HPV vaccine approval. However, oropharyngeal and anal/rectal cancers have increased among men. Meaning These findings suggest that the decrease in the incidence of cervical cancers, particularly in young women may be associated with HPV vaccination approval; however, it may be too early to evaluate this association in oropharyngeal and anal cancers, which occur later in life.