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Key Points Question Are age, intellectual disability (ID), and clinical status associated with Alzheimer disease (AD) progression and longitudinal cognitive decline in adults with Down syndrome (DS)? Findings In this… Click to show full abstract
Key Points Question Are age, intellectual disability (ID), and clinical status associated with Alzheimer disease (AD) progression and longitudinal cognitive decline in adults with Down syndrome (DS)? Findings In this cohort study of 632 adults with DS, there was a high age-dependent risk of developing symptomatic AD but not the prodromal stage of the disease. ID stratification was not associated with longitudinal cognitive decline, and the study found both practice and floor effects. Meaning These findings show the need for health plans to screen for AD in adults with DS and provide important data to inform AD clinical trials.
Journal Title: JAMA Network Open
Year Published: 2022
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