LAUSR

Key Points Question What are the associations of changes in body weight, waist circumference, or both, with all-cause mortality? Findings Using data from 2 cohort studies of 58 132 Chinese adults, this cohort study found U-shape associations of changes in weight and waist circumference with mortality risk. In addition, when changes in weight and waist circumference were jointly assessed, compared with participants who had stable weight (change ≤2.5 kg) and waist circumference (change ≤3.0 cm), those who lost more than 2.5 kg of weight but gained more than 3.0 cm of waist circumference had the highest risk of all-cause mortality among the joint subgroups. Meaning Among middle-aged and older Chinese adults, people who lost weight but gained waist circumference had a much higher risk of mortality.