LAUSR

Key Points Question What is the validity of prediction models that use sociodemographic, lifestyle, and health state factors to predict health-related quality of life (HRQOL) among adult survivors of childhood cancer? Findings In this prognostic study of 4755 adult survivors of childhood cancer, chronic health conditions were associated with a decline in physical HRQOL, whereas current cigarette smoking and emotional and neurocognitive impairment were associated with a decline in mental HRQOL. Performance based on the area under receiver operator characteristic curve was 0.74 for declining physical HRQOL and 0.68 for declining mental HRQOL. Meaning These findings may help guide clinicians to screen for risk factors during follow-up appointments and provide interventions that target these risk factors to prevent poor HRQOL among adult survivors of childhood cancer.