LAUSR

Key Points Question What is the effect of losartan on lung injury in hospitalized patients with COVID-19? Findings In this randomized clinical trial in 205 patients with evidence of COVID-19–induced acute lung injury, angiotensin receptor blockade with maximal dose losartan did not reduce lung injury at 7 days, as measured by partial pressure of oxygen to fraction of inspired oxygen ratio. Secondary outcomes, including ventilator-free days and mortality, were unaffected, but patients treated with losartan had fewer vasopressor-free days. Meaning This randomized clinical trial found that losartan for angiotensin receptor blockade did not reduce lung injury in patients with COVID-19 and raised concerns about risks of harm.