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Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis

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Key Points Question Are kidney health outcomes different in children and adolescents compared with adults with focal segmental glomerulosclerosis (FSGS)? Findings This cohort study with 482 patients from 3 independent… Click to show full abstract

Key Points Question Are kidney health outcomes different in children and adolescents compared with adults with focal segmental glomerulosclerosis (FSGS)? Findings This cohort study with 482 patients from 3 independent cohorts found no significant differences by age in the median time to kidney failure, 11.9 years, or to the composite outcome of time to kidney failure or 40% reduction in kidney function, 5.7 years, despite differences in clinical context and medical management. Meaning These findings suggest that the adverse outcomes of FSGS on kidney survival are severe and comparable across the lifespan.

Keywords: kidney health; focal segmental; kidney; health outcomes; children adolescents; adults focal

Journal Title: JAMA Network Open
Year Published: 2022

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