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Key Points Question Are preconception thyrotropin levels associated with fecundability and risk of spontaneous abortion? Findings In this cohort study of 11 194 002 participants in China, participants with preconception thyrotropin levels… Click to show full abstract
Key Points Question Are preconception thyrotropin levels associated with fecundability and risk of spontaneous abortion? Findings In this cohort study of 11 194 002 participants in China, participants with preconception thyrotropin levels outside reference range were significantly more likely to experience delayed time to pregnancy and increased risk of spontaneous abortion. A preconception thyrotropin level of 0.37 to 2.49 mIU/L was associated with the lowest risk of these unfavorable outcomes. Meaning The findings of this study suggest that interventional studies investigating the benefits of preconception thyroid function screening and levothyroxine supplementation are warranted.
Journal Title: JAMA Network Open
Year Published: 2022
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