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Hospital and Neurodevelopmental Outcomes in Nano-Preterm Infants Receiving Invasive vs Noninvasive Ventilation at Birth

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Key Points Question Is intubation at 10 minutes or less after birth associated with a higher incidence of bronchopulmonary dysplasia or death by 36 weeks’ postmenstrual age in nano-preterm (22… Click to show full abstract

Key Points Question Is intubation at 10 minutes or less after birth associated with a higher incidence of bronchopulmonary dysplasia or death by 36 weeks’ postmenstrual age in nano-preterm (22 0/7 to 23 6/7 weeks’ gestational age) infants? Findings This cohort study of 230 nano-preterm infants found that the incidence of bronchopulmonary dysplasia or death by 36 weeks’ postmenstrual age did not significantly differ between those exposed to noninvasive and invasive respiratory support at birth. Noninvasive respiratory support at birth may be associated with a higher risk of severe intraventricular hemorrhage or death by 36 weeks’ postmenstrual age in nano-preterm infants. Meaning These findings suggest that noninvasive respiratory support in the first 10 minutes after birth is feasible in the treatment of nano-preterm infants, although it may be associated with an increased incidence of severe intraventricular hemorrhage or death by 36 weeks’ postmenstrual age.

Keywords: nano preterm; age; death weeks; weeks postmenstrual; birth; preterm infants

Journal Title: JAMA Network Open
Year Published: 2022

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