LAUSR

Key Points Question Are genetic predisposition to diabetes and physical activity in early pregnancy cooperatively associated with risk of gestational diabetes (GD) among nulliparous women? Findings In this cohort study of 3533 women, a high polygenic risk score (PRS) and low level of physical activity were associated with increased risk of GD. The estimated odds for participants with high PRS and low level of physical activity was 3.4 but was near or less than the baseline level of 1.0 with either low PRS or high activity. Meaning These findings suggest that physical activity in early pregnancy is associated with reduced risk of GD and reversal of excess risk in genetically predisposed individuals, and PRS may have utility in identifying women for targeted interventions.