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Risk Levels and Adverse Clinical Outcomes Among Patients With Nonvalvular Atrial Fibrillation Receiving Oral Anticoagulants

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Key Points Question What are the relative safety and effectiveness outcomes among patients with nonvalvular atrial fibrillation receiving anticoagulants by CHA2DS2-VASc risk score range, thromboembolic event history, and age group?… Click to show full abstract

Key Points Question What are the relative safety and effectiveness outcomes among patients with nonvalvular atrial fibrillation receiving anticoagulants by CHA2DS2-VASc risk score range, thromboembolic event history, and age group? Findings In this cohort study including data from more than 1 million patients, the observed incidence of stroke, systemic embolism, and major bleeding events generally conformed to an expected increasing incidence by risk score. Meaning These results suggest that the assessment of individual baseline risk profiles can better inform clinical decision-making, research, and policy for this patient population.

Keywords: outcomes among; patients nonvalvular; risk; among patients; atrial fibrillation; nonvalvular atrial

Journal Title: JAMA Network Open
Year Published: 2022

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