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Assisted Reproductive Technology and Risk of Childhood Cancers

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Key Points Question Are children conceived via assisted reproductive technology (ART) at a higher risk of childhood cancers? Findings In this nationwide population-based cohort study of 2 308 016 parents-child triads in… Click to show full abstract

Key Points Question Are children conceived via assisted reproductive technology (ART) at a higher risk of childhood cancers? Findings In this nationwide population-based cohort study of 2 308 016 parents-child triads in Taiwan, children conceived via ART were at a statistically significant increased risk for childhood cancers compared with children conceived naturally and those born to parents with an infertility diagnosis who did not use ART. This association was not mediated by preterm birth and low birth weight. Meaning The findings suggest that ART conception is associated with an increased risk for childhood cancers, and the increased risk cannot be attributed to preterm birth or low birth weight.

Keywords: reproductive technology; risk; assisted reproductive; childhood cancers; risk childhood

Journal Title: JAMA Network Open
Year Published: 2022

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