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Key Points Question Is childhood adversity associated with acceleration of aging and, if so, does lifestyle mediate the association? Findings In this cohort study of 127 495 adults aged 40 to… Click to show full abstract
Key Points Question Is childhood adversity associated with acceleration of aging and, if so, does lifestyle mediate the association? Findings In this cohort study of 127 495 adults aged 40 to 69 years in the UK Biobank, childhood adversity was significantly associated with acceleration of phenotypic aging, and unhealthy lifestyle partially mediated the associations by 11.8% to 42.1%. Meaning These findings reveal a pathway from childhood adversity to health in middle and early older adulthood through modifiable lifestyle and underscore the potential of more psychological strategies beyond lifestyle interventions to promote healthy aging.
Journal Title: JAMA Network Open
Year Published: 2022
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