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Key Points Question Does supplementation with vitamin D3 and/or omega-3 fatty acids reduce the risk of frailty? Findings In this ancillary study of a randomized clinical trial including 25 871 individuals… Click to show full abstract
Key Points Question Does supplementation with vitamin D3 and/or omega-3 fatty acids reduce the risk of frailty? Findings In this ancillary study of a randomized clinical trial including 25 871 individuals aged 50 years or older, neither vitamin D3, 2000 IU/d, nor omega-3 fatty acid, 1 g/d, supplementation, compared with placebo, significantly affected change in frailty score during 5 years of treatment. Results were unchanged using the frailty physical phenotype. Meaning The results of this ancillary study do not support the routine use of vitamin D3 or omega-3 fatty acid supplementation in community-dwelling older adults for the prevention of frailty.
Journal Title: JAMA Network Open
Year Published: 2022
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