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Use and Reporting of Patient-Reported Outcomes in Trials of Palliative Radiotherapy

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Key Points Question How commonly are patient-reported outcomes (PROs) used and how well are they reported in clinical trials of palliative radiotherapy? Findings In this systematic review that included 225… Click to show full abstract

Key Points Question How commonly are patient-reported outcomes (PROs) used and how well are they reported in clinical trials of palliative radiotherapy? Findings In this systematic review that included 225 published clinical trials representing 24 281 patients, only 20% of trials used PROs as a primary end point and 31% as a secondary end point. The reporting of PROs was poor or moderate for most items of the Consolidated Standards of Reporting Trials PRO extension, while the use of a PRO as a primary end point was significantly associated with better reporting. Meaning These findings suggest that the current use and reporting of PROs has room for improvement in future trials of palliative radiotherapy.

Keywords: reported outcomes; trials palliative; patient reported; palliative radiotherapy; use

Journal Title: JAMA Network Open
Year Published: 2022

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