LAUSR

Key Points Question What are the temporal patterns in the use of oseltamivir among children hospitalized with influenza, and what patient factors are associated with its use? Findings In this cross-sectional study of 70 473 children hospitalized with influenza in the US between 2007 and 2020, oseltamivir use increased over time, from 20.2% in the 2007-2008 influenza season to a peak of 77.9% in the 2017-2018 season, with wide institutional variation. Oseltamivir was used more frequently among children who were critically ill, children who were older, and children who had high-risk conditions. Meaning This study’s findings suggest that although the use of oseltamivir has increased over time, further work is needed to address guideline adherence and evaluate the impact of oseltamivir administration for outcomes.