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Key Points Question What is the estimated vaccine effectiveness (VE) of mRNA COVID-19 vaccines against medically attended COVID-19 during pregnancy? Findings In a case-control study including 5492 health care encounters… Click to show full abstract
Key Points Question What is the estimated vaccine effectiveness (VE) of mRNA COVID-19 vaccines against medically attended COVID-19 during pregnancy? Findings In a case-control study including 5492 health care encounters sought by pregnant people, the estimated 2-dose VE against COVID-19–associated emergency department and urgent care encounters during Omicron predominance was not significantly different from 0; estimated 3-dose VE (last dose 7-119 days prior) was 79%. Against COVID-19–associated hospitalizations, 2-dose VE (14-149 days prior) was 86%, and 3-dose VE (7-119 days prior) was 86%; 2- and 3-dose VE estimates were not statistically different from 0 for doses 150 and more and 120 and more days prior. Meaning In this study, maternal vaccination, including booster dose, was associated with protection against serious COVID-19 during pregnancy.
Journal Title: JAMA Network Open
Year Published: 2022
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