LAUSR

Key Points Question What is the association of antenatal steroid administration at 22 weeks’ gestational age (GA) or earlier with survival and morbidities in extremely preterm neonates? Findings In this cohort study among 431 infants born between GA 22 0/7 and 23 6/7 weeks who received intensive care, exposure to a complete course of antenatal steroids at GA 21 to 22 weeks was independently associated with higher survival, compared with partial antenatal corticosteroids and no antenatal steroids. Meaning These findings suggest that antenatal steroids should be administered promptly even for patients at risk of delivery at 22 weeks of gestation when postnatal resuscitation is planned, as exposure to a complete course of antenatal steroids was associated with significant improvement in survival and decreased morbidity.