LAUSR

Key Points Question What are the causes and potential factors associated with death after lower extremity osseointegration? Findings In this cohort study of 485 patients who underwent transcutaneous osseointegration post amputation and were followed up for as long as 10 years, 19 patients (4%) died, including 17 who died of causes unrelated to osseointegration and 2 who died of osseointegration-related causes. Risk factors for mortality included increased age at osseointegration and the indication for amputation being either for vascular or infectious etiology; factors not associated with mortality risk included postosseointegration infection and sex. Meaning These findings suggest that patients considering osseointegration to improve their mobility and quality of life have a minimal risk of mortality.