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Key Points Question What is the available evidence regarding cases of hepatitis of unknown etiology in children in 2021 to 2022? Findings This systematic review without meta-analysis identified 1643 cases… Click to show full abstract
Key Points Question What is the available evidence regarding cases of hepatitis of unknown etiology in children in 2021 to 2022? Findings This systematic review without meta-analysis identified 1643 cases across 22 studies, with 120 children (7%) receiving liver transplants and 24 deaths (1%). Testing focused on adenovirus, SARS-CoV-2, and adeno-associated virus 2. Meaning These findings suggest that the cause of novel hepatitis in children remains undetermined, but the potential role of adenovirus, adeno-associated virus 2, and SARS-CoV-2 requires further exploration in multicenter collaborative studies.
Journal Title: JAMA Network Open
Year Published: 2022
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