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Key Points Question What are the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and mortality in preterm infants? Findings In this… Click to show full abstract
Key Points Question What are the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and mortality in preterm infants? Findings In this cohort study of 1221 preterm infants who received ventilation, platelet transfusion was associated with an increased risk of mortality, while decreased PC was associated with increased risks of IVH and mortality. The platelet transfusion–associated risks of IVH and mortality varied according to PC and MPV levels at the time of transfusion. Meaning These findings suggest that a lower platelet transfusion threshold is preferred, while the risk of a low PC should not be neglected.
Journal Title: JAMA Network Open
Year Published: 2022
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