LAUSR

Key Points Question Is vaginal progesterone treatment associated with reduced risk of recurrent spontaneous preterm birth (gestational age, ≤35 weeks) among patients with singleton pregnancies? Findings In this cohort study of 417 pregnant patients with previous preterm births, use of vaginal progesterone was not associated with a reduction in preterm birth when accounting for both frequency and severity of prior preterm births. Meaning This study suggests that, for patients with prior preterm birth, vaginal progesterone treatment was not associated with a reduction in recurrence of preterm birth.