LAUSR

Key Points Question Is hormonal therapy (HT) during menopause associated with risk of developing depression? Findings In this cohort study including all Danish women aged 45 years followed up for a mean of 11 years, initiation of systemically administrated HT before 50 years of age was associated with higher risk of depression. Locally administered HT was associated with lower risk of depression for women older than 54 years. Meaning These findings suggest that women undergoing menopause who initiate systemically administered HT should be aware of depression as a potential adverse effect, and locally administered HT should be recommended when needed.