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Key Points Question Is epigenetic aging associated with neonatal brain growth and neurodevelopmental outcomes among very preterm neonates? Findings In this cohort study of 35 neonates, accelerated epigenetic aging—measured by… Click to show full abstract
Key Points Question Is epigenetic aging associated with neonatal brain growth and neurodevelopmental outcomes among very preterm neonates? Findings In this cohort study of 35 neonates, accelerated epigenetic aging—measured by the pediatric buccal epigenetic clock—was associated with smaller brain volumes at term-equivalent age and slower brain growth during the neonatal period, as well as worse neurodevelopmental outcomes at 18 months of age. Meaning This study suggests that biological epigenetic aging among very preterm neonates may be an indicator of brain growth and neurodevelopmental outcomes, and its application requires further investigation.
Journal Title: JAMA Network Open
Year Published: 2022
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