LAUSR

Key Points Question Does the enrollment of patients from racial and ethnic minority groups in US phase 1 drug trials for metastatic cancer reflect the makeup of the US population with metastatic cancer? Findings This cross-sectional study compared the proportions of racial and ethnic groups in 221 phase 1 trials from 2000 to 2018 with population-based cancer registry data and found worsening underrepresentation of American Indian or Alaska Native, Asian or Pacific Islander, Black, and Hispanic or Latinx participants over time. Meaning This study suggests that there need to be more efforts to diversify participation in early cancer drug clinical trials to ensure that safety and efficacy findings are generalizable across racial and ethnic populations.