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Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively… Click to show full abstract
Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with Alzheimer disease (AD)? Findings In this cross-sectional study of 243 patients with AD and controls, CSF Klotho levels were significantly higher among controls and individuals with mild cognitive impairment due to AD compared with individuals with dementia due to AD. Furthermore, CSF Klotho levels were significantly associated with lower levels of CSF AD core biomarkers independent of clinical, KL-VS heterozygosity, or APOE4 status. Meaning These findings suggest that Klotho protein levels, but not KL-VS heterozygosity status, differ in clinical stages of AD and are associated with amyloid and tau burden.
Journal Title: JAMA Network Open
Year Published: 2022
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