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Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia

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Key Points Question What is the rate of exposure to antibiotics and the incidence of early-onset sepsis (EOS) and sepsis-associated mortality among late-preterm and full-term newborns? Findings In this cross-sectional… Click to show full abstract

Key Points Question What is the rate of exposure to antibiotics and the incidence of early-onset sepsis (EOS) and sepsis-associated mortality among late-preterm and full-term newborns? Findings In this cross-sectional study of 757 979 neonates born in 13 networks from 11 countries, 2.86% received antibiotics during the first postnatal week (range across networks, 1.18%-12.45%). The incidence of EOS was 0.49 cases per 1000 live births (range, 0.18-1.45 cases per 1000 live births), and the EOS-associated mortality rate was 3.20%. Meaning Early postnatal antibiotic use was high compared with the rate of sepsis and varied across networks, suggesting it could be lowered safely.

Keywords: sepsis; early onset; antibiotic exposure; analysis antibiotic

Journal Title: JAMA Network Open
Year Published: 2022

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