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Key Points Question Is rituximab more effective than cyclophosphamide for treatment of granulomatosis with polyangiitis (GPA)? Findings In this comparativeness effectiveness study based on clinical data from 194 patients with… Click to show full abstract
Key Points Question Is rituximab more effective than cyclophosphamide for treatment of granulomatosis with polyangiitis (GPA)? Findings In this comparativeness effectiveness study based on clinical data from 194 patients with GPA, rituximab as induction therapy was associated with significantly more achievement of remission with a prednisone dose of 10 mg/d or less compared with cyclophosphamide. Rare disease registries and comparative effectiveness studies enable hitherto poorly addressed treatment comparisons for such entities. Meaning These findings may inform clinical decision-making regarding the choice of remission-inducing regimen for patients with GPA.
Journal Title: JAMA Network Open
Year Published: 2022
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