LAUSR

Key Points Question Can oral butyrate supplementation as adjunct to standard care be effective in the treatment of pediatric obesity? Findings In this randomized clinical trial including 54 children with obesity, a 40% absolute increase in the rate of children experiencing a decrease of at least 0.25 SD scores of body mass index was observed at 6 months in those treated with butyrate compared with those receiving placebo in an intention-to-treat analysis. Adverse effects included transient mild nausea and headache reported by 2 patients during the first month of butyrate intervention. Meaning The findings of this randomized clinical trial suggest that oral butyrate supplementation may be effective in the treatment of pediatric obesity.