LAUSR

Key Points Question Does erythropoietin improve behavior and health-related quality of life in children aged 5 years who were born very preterm? Findings In this secondary analysis of a randomized clinical trial that included 448 infants born between 26 and 32 weeks’ gestational age randomized to high-dose erythropoietin or placebo within the first 48 postnatal hours, parent-rated behavior and health-related quality of life outcomes did not differ at age 5 years. Meaning This randomized clinical trial found that prophylactic early high-dose erythropoietin did not affect behavior or health-related quality of life at age 5 years among children born very preterm.