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Key Points Question What is the association between immune-related adverse events (irAEs) and survival after immune checkpoint inhibitor (ICI) therapy initiation and human leukocyte antigen genes in patients with advanced… Click to show full abstract
Key Points Question What is the association between immune-related adverse events (irAEs) and survival after immune checkpoint inhibitor (ICI) therapy initiation and human leukocyte antigen genes in patients with advanced malignant melanoma? Findings In this case-control study of 132 adults with advanced malignant melanoma treated with ICIs, patients with irAEs had improved treatment response rates and better survival. Distinct HLA-DR alleles were associated with specific irAEs. Meaning These findings suggest that the occurrence of irAEs after ICI therapy in patients with advanced melanoma is associated with improved treatment response, survival, and certain HLA-DR alleles.
Journal Title: JAMA Network Open
Year Published: 2022
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