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Key Points Question Is a polygenic risk score (PRS) derived from European ancestry data associated with Alzheimer disease (AD) dementia risk in non-European populations? Findings In this cohort study of… Click to show full abstract
Key Points Question Is a polygenic risk score (PRS) derived from European ancestry data associated with Alzheimer disease (AD) dementia risk in non-European populations? Findings In this cohort study of genome data from European and Asian databases of patients with AD, a PRS derived from a genome-wide study of individuals with European ancestry was associated with high genetic risk for AD dementia in 1634 Korean individuals. Furthermore, the PRS was associated with amnestic mild cognitive impairment, earlier symptom onset of AD dementia, and amyloid β deposition. Meaning These findings emphasize the transancestry transferability and clinical value of PRSs and reinforce the need for enriching diversity in genetic studies of AD.
Journal Title: JAMA Network Open
Year Published: 2022
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