LAUSR

Key Points Question What is the incidence of esophageal squamous cell carcinoma (ESCC) in patients with low-grade intraepithelial neoplasia (LGIN) and is there an association between surveillance endoscopy and ESCC incidence? Findings In this cohort study of 3258 patients with LGIN in China, the cumulative ESCC incidence was 6.28 per 1000 person-years during a median follow-up of 7.96 years. Patients in the surveillance group had a 31% decreased risk of ESCC incidence. Meaning The findings of this study present insights into the efficiency of surveillance endoscopy for patients with LGIN in the Chinese population, thereby providing evidence for surveillance guidelines for ESCC.