LAUSR

Key Points Question Does CYP1A2 genotype modify the association between coffee intake and kidney dysfunction? Findings In this cohort study involving a 7.5-year follow-up of 1180 untreated participants with stage 1 hypertension from the Hypertension and Ambulatory Recording Venetia Study, those with a genetic variant in CYP1A2 who were slow metabolizers of caffeine were 2.7 times more likely to develop albuminuria, 2.5 times more likely to develop hyperfiltration, and 2.8 times more likely to develop hypertension with heavy coffee intake compared with low coffee intake. No associations were observed between coffee intake and albuminuria, hyperfiltration, or hypertension among fast metabolizers of caffeine. Meaning These findings suggest that heavy coffee intake is associated with increases in the risk of kidney dysfunction among slow metabolizers of caffeine, who genetically comprise approximately half of the population, but not among fast metabolizers of caffeine.