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Key Points Question Are peripheral neuropathies associated with altered levels of blood-based biomarkers related to nerve involvement? Findings This systematic review and meta-analysis included 36 studies reporting on 4414 participants,… Click to show full abstract
Key Points Question Are peripheral neuropathies associated with altered levels of blood-based biomarkers related to nerve involvement? Findings This systematic review and meta-analysis included 36 studies reporting on 4414 participants, including 2301 patients with peripheral neuropathy and 2113 controls. Neurofilament light chain was the most commonly reported marker (17 studies) and demonstrated significantly increased serum or plasma concentrations in patients with peripheral neuropathy compared with controls. Meaning These findings suggest that a blood-based measure of neurofilament light chain may be a useful indicator of neuronal injury in patients with peripheral neuropathy.
Journal Title: JAMA Network Open
Year Published: 2022
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