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Key Points Question Does targeting MUC5AC with the NPC-1C antibody augment the antitumor activity of gemcitabine plus nab-paclitaxel as a second-line treatment for pancreatic cancer? Findings In this randomized phase… Click to show full abstract
Key Points Question Does targeting MUC5AC with the NPC-1C antibody augment the antitumor activity of gemcitabine plus nab-paclitaxel as a second-line treatment for pancreatic cancer? Findings In this randomized phase 2 trial of 78 patients with advanced pancreatic cancer who previously progressed on first-line FOLFIRINOX, the addition of NPC-1C to second-line gemcitabine plus nab-paclitaxel did not prolong overall survival. Meaning Although NPC-1C did not enhance the efficacy of gemcitabine plus nab-paclitaxel in second-line advanced pancreatic cancer, this study establishes efficacy benchmarks, dose modification patterns, and characteristics associated with survival among patients receiving second-line gemcitabine plus nab-paclitaxel.
Journal Title: JAMA Network Open
Year Published: 2023
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