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Key Points Question What are the outcomes of patients receiving proton therapy reirradiation for head and neck squamous cell carcinoma (HNSCC)? Findings This cohort study of 242 patients with HNSCC… Click to show full abstract
Key Points Question What are the outcomes of patients receiving proton therapy reirradiation for head and neck squamous cell carcinoma (HNSCC)? Findings This cohort study of 242 patients with HNSCC found 1-year local control of 71.8% and 1-year overall survival of 66.6% for those receiving fractionated reirradiation. The study found 79 potential grade 3, 4 grade 4, and 5 grade 5 late toxic effects. Meaning These findings suggest that proton therapy reirradiation may be associated with improved survival for patients with HNSCC, but the toxic effects may be substantial.
Journal Title: JAMA Network Open
Year Published: 2023
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