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Key Points Question At what age do individuals with higher genetic risk of Alzheimer disease first show cognitive differences from individuals with lower genetic risk, and which of 32 cognitive… Click to show full abstract
Key Points Question At what age do individuals with higher genetic risk of Alzheimer disease first show cognitive differences from individuals with lower genetic risk, and which of 32 cognitive measures show the earliest difference? Findings In this cross-sectional study of 405 050 individuals, higher genetic risk of Alzheimer disease significantly modified the association of age with 13 of 32 cognitive measures. Best-fitting models suggested that higher genetic risk of Alzheimer disease was associated with changes in cognitive scores of individuals older than 56 years for all 13 measures and older than 47 years for 9 measures. Meaning These findings suggest that by early midlife, subtle differences in cognitive measures may emerge among individuals with higher genetic risk of Alzheimer disease.
Journal Title: JAMA Network Open
Year Published: 2022
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