LAUSR

Key Points Question Is short-term oral rivaroxaban a noninferior alternative to parenteral enoxaparin in the acute phase of acute coronary syndrome (ACS)? Findings This equivalence and noninferiority trial including 2046 patients found that short-term rivaroxaban 5 mg twice daily was noninferior to enoxaparin in terms of bleeding risk and efficacy in reducing major adverse cardiovascular events during 6 months of follow-up among patients with ACS who missed the primary reperfusion window and before selective revascularization. Meaning These findings suggest that rivaroxaban-5 mg twice daily may be a reasonable alternative to enoxaparin in the acute phase of ACS, which may provide useful information for designing future definitive randomized clinical trials with sufficient sample sizes.