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Key Points Question Is treatment with antipsychotics in children and adolescents who are taking antidepressant medications associated with neurological adverse events? Findings In this cohort study of 9890 children and… Click to show full abstract
Key Points Question Is treatment with antipsychotics in children and adolescents who are taking antidepressant medications associated with neurological adverse events? Findings In this cohort study of 9890 children and adolescents prescribed antidepressants for depression, the hazard ratios of movement disorders and seizures with adjuvant antipsychotics were 2- to 3-fold higher compared with antidepressant monotherapy. Hazard ratios increased with increasing doses of adjuvant antipsychotics and varied according to which antipsychotic was concomitantly used. Meaning These results suggest that adjuvant use of antipsychotics needs to be carefully considered in the treatment children and adolescents with depression.
Journal Title: JAMA Network Open
Year Published: 2022
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