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Key Points Question Is high-dose vitamin D supplementation safe for children aged 0 to 6 years? Findings In this systematic review and meta-analysis of 32 randomized clinical trials including 8400… Click to show full abstract
Key Points Question Is high-dose vitamin D supplementation safe for children aged 0 to 6 years? Findings In this systematic review and meta-analysis of 32 randomized clinical trials including 8400 unique children, high-dose vitamin D administered as a daily or bolus supplement was not associated with an increased risk of serious adverse events. Clinical adverse events associated with the supplementation were rare. Meaning This systematic review and meta-analysis suggests that vitamin D supplements in daily doses to 10 000 IU/d or bolus doses to 600 000 IU are well tolerated in children aged 0 to 6 years.
Journal Title: JAMA Network Open
Year Published: 2022
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