LAUSR

Key Points Question Is traumatic brain injury (TBI) with and without loss of consciousness (LOC) associated with dementia-related neuropathologic outcomes in older persons? Findings In this cross-sectional analysis of 1689 autopsied participants from 3 community-based cohort studies, participants with TBI with LOC had greater amyloid-β burden and higher odds of gross infarcts and microinfarcts, whereas those with TBI without LOC had higher odds of neocortical Lewy bodies and cortical microinfarcts. Meaning Even without LOC, TBI may be associated with higher odds of neurodegenerative and vascular pathologic findings in later life.