LAUSR

Key Points Question What are the clinical outcomes of patients with intracranial metastatic disease in the setting of stable extracranial disease (IMD-SE) compared with patients with brain metastases and progressive extracranial disease (IMD-PE)? Findings This meta-analysis of 68 studies found prolonged overall survival in patients with IMD-SE compared with those with IMD-PE. Pooled median overall survival for patients with IMD-SE was 20.9 months, and weighted median overall survival was 17.9 months for patients with IMD-SE and 8.0 months for patients with IMD-PE. Meaning These results suggest that IMD-SE represents a subgroup of patients with intracranial metastatic disease who have favorable survival.