LAUSR

Key Points Question Is exposure to gestational diabetes, gestational hypertension, or preeclampsia associated with biological gestational age, measured via epigenetic clocks, in newborns? Findings In this national multisite cohort study of 1801 children, preeclampsia and gestational diabetes were significantly associated with decelerated gestational age in exposed offspring at birth vs unexposed offspring (ie, they were estimated to be biologically younger than their chronological gestational age), and these associations were more pronounced in female offspring. No associations were observed for gestational hypertension and accelerated or decelerated biological age. Meaning These findings suggest that the epigenetic developmental aging pathway is an important biological pathway associated with 2 pregnancy conditions and may play a role in mediating the effects of these conditions on perinatal and child health outcomes, particularly among female offspring.