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Key Points Question Can volatile organic compounds (VOCs) in exhaled breath provide diagnostic information on COVID-19 disease and SARS-CoV-2 variants? Findings In this diagnostic study with 167 participants, 4 VOC… Click to show full abstract
Key Points Question Can volatile organic compounds (VOCs) in exhaled breath provide diagnostic information on COVID-19 disease and SARS-CoV-2 variants? Findings In this diagnostic study with 167 participants, 4 VOC biomarkers were found to distinguish between the Delta variant of SARS-CoV-2 (and other variants occurring in 2021) from non–COVID-19 illness. The emergence of the Omicron variant in 2022 substantially affected the VOC profiles, requiring a different set of VOCs to distinguish between the Omicron variant and non–COVID-19 illness. Meaning These findings demonstrate the ability of breath analysis to distinguish between COVID-19 and non–COVID-19 illness, but they also reveal the significant variations in the breath profile among patients with COVID-19 as new SARS-CoV-2 variants emerge.
Journal Title: JAMA Network Open
Year Published: 2023
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