LAUSR

Key Points Question Is intravenous sodium thiosulphate (STS) treatment associated with improvement in skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Findings This meta-analysis of 19 cohort studies examining STS treatment for patients with CKD experiencing calciphylaxis did not show an association between intravenous STS and skin lesion improvement or survival benefits compared with non-STS group. Meaning These results suggest that studies of intravenous STS on patients with CKD experiencing calciphylaxis have not found an improvement in skin lesion outcomes or survival. Future studies that rigorously evaluate therapies applied to patients with calciphylaxis are urgently needed.