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Key Points Question For patients completing stereotactic radiosurgery (SRS) for brain metastases, are intracranial and extracranial progression reliable surrogates for overall survival (OS)? Findings In this cohort study of 1383… Click to show full abstract
Key Points Question For patients completing stereotactic radiosurgery (SRS) for brain metastases, are intracranial and extracranial progression reliable surrogates for overall survival (OS)? Findings In this cohort study of 1383 patients undergoing an initial course of SRS, both intracranial and extracranial progression-free survival were correlated with OS, with median durations approximately half that of OS. Meaning These findings may support inclusion of patients with brain metastases completing SRS in oncologic clinical trials with composite primary outcomes.
Journal Title: JAMA Network Open
Year Published: 2023
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